For anyone prescribed lithium, and for the family member who helps with medicines.

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The blood test
- Lithium works only within a narrow range in the blood. Too little does not work. Too much is poisonous.
- The sample is taken 12 hours after your last dose. Take the night dose as usual and give blood the next morning, before the morning dose.
- At the start and after any dose change, the level is tested every week until it is steady. Then every 3 months for the first year, and every 3 to 6 months after that.
- Kidney function, thyroid and calcium are tested every 6 months.
Every day
- Take it at the same time each day. Stay on the same brand: different brands release lithium differently.
- Missed a dose? If it is less than 6 hours late, take it. If it is later than that, skip it and take the next one at the usual time. Never take a double dose.
- Drink fluids regularly, more in hot weather and after exercise or sweating.
- Keep your salt intake steady. Do not start a low-salt diet without telling your doctor. Less salt makes the lithium level rise.
- If you plan to fast, speak to your doctor first about fluids and the timing of doses.
- Limit alcohol.
Medicines that raise the lithium level
- Painkillers such as ibuprofen, diclofenac, aceclofenac, naproxen and nimesulide, and combination pain and cold tablets that contain them. Use plain paracetamol instead.
- Blood pressure tablets ending in -pril or -sartan, and tablets that make you pass more urine. Do not stop these yourself: tell the doctor who prescribes your lithium, so that your level can be checked.
- Some antibiotics, such as metronidazole
- Tell every doctor and chemist that you take lithium before any new medicine is started.
Common effects at a normal level
- Fine tremor of the hands, thirst, passing more urine, mild nausea, a metallic taste, some weight gain. Tell your doctor at the next visit.
Signs of too much lithium: take no more lithium and go to a hospital now
- Vomiting again and again, or severe loose motions
- Coarse shaking of the hands, or twitching muscles
- Unsteady walking, as if drunk
- Slurred speech
- Drowsiness or confusion
- Blurred vision
- A fit, or collapse: call 108
Go to the nearest hospital with an emergency department and say that you take lithium. A lithium level is needed urgently.
Contact your doctor promptly if
- You have fever, or mild vomiting or loose motions, without the signs above. Phone the doctor the same day, before your next dose: it may need to be paused.
- You are pregnant, planning a pregnancy or breastfeeding. Lithium can affect the baby's heart. Use reliable contraception, and do not stop the tablet on your own.
- You want to stop lithium. Stopping suddenly brings a high risk of relapse. It is reduced slowly, over at least 4 weeks.
Questions about this sheet? Call Caspian Healthcare reception on +91 89193 41154. A doctor is on duty at all hours for problems that are not critical. Caspian has no emergency department: in an emergency call 108.
Where this comes from
- Indian Psychiatric Society: clinical practice guidelines for management of bipolar disorder, 2017
- NHS: lithium, how and when to take it
- NHS: side effects of lithium
- NHS: taking lithium with other medicines
- Nottinghamshire Area Prescribing Committee: lithium prescribing guideline (after NICE CG185)
Prepared by Caspian Healthcare from the sources above. Last reviewed October 2026. General information: your own doctor's written instructions come first.