For anyone with diabetes who is unwell with fever, vomiting, loose motions or an infection.

Fill in, then print
The five rules
- Never stop your insulin, even if you are not eating. Illness usually pushes sugar up, and you may need more insulin. Long-acting insulin is needed every day. If you are not eating and your sugar is falling, mealtime or premixed insulin may need reducing: call your doctor.
- Test more often. On insulin: every 2 to 4 hours, including at night. On tablets: at least 4 times a day.
- Drink. A glass (about 200 ml) every hour while awake, unless your doctor has limited your fluids. Small sips every 15 minutes if you feel sick.
- Keep some food going in. If you cannot eat meals, take a small amount every 1 to 2 hours. Any one of: half a glass of fruit juice, a glass of milk, a cup of soup, or two plain biscuits.
- Pause the medicines in the table while you are vomiting, have loose motions or cannot drink.
Medicines to pause while you are losing fluid
| Medicine | Why |
|---|---|
| Any medicine ending in -gliflozin (dapagliflozin, empagliflozin, remogliflozin and others, alone or in a combination tablet) | Can cause a dangerous acid build-up (ketoacidosis) during illness, even when the sugar reading is normal. |
| Metformin | Can build up if the kidneys are affected by dehydration. |
| Blood pressure tablets ending in -pril or -sartan, and tablets that make you pass more urine (such as furosemide or torsemide) | Can harm the kidneys when you are short of fluid. |
| Painkillers such as ibuprofen and diclofenac | The same reason. Use paracetamol instead. |
| Glimepiride, gliclazide and similar tablets | Can cause low sugar if you are not eating. Ask the doctor whether to reduce or skip. |
Start them again 24 to 48 hours after you are eating and drinking normally. If you take a weekly injection for diabetes or weight and are vomiting, ask the doctor before the next dose.
Check ketones
If you have type 1 diabetes, are pregnant, or take a -gliflozin medicine, test for ketones whenever your sugar is above 250 mg/dL, you are vomiting, or you feel very unwell. Use a blood ketone meter or urine ketone strips.
| Blood ketones (mmol/L) | Urine strip | What to do |
|---|---|---|
| Below 0.6 | Negative | Normal. Keep testing. |
| 0.6 to 1.5 | Trace or + | Drink more. Test again in 2 hours. |
| 1.6 to 2.9 | ++ | Call your doctor now. You may need extra insulin. |
| 3.0 or more | +++ or more | Emergency. Go to hospital. |
Go to a hospital now if
- You cannot keep fluids down, or have vomited more than 3 times in 24 hours
- You have deep or fast breathing, pain in the stomach area, or unusual sleepiness
- Your breath smells sweet or fruity
- Your sugar stays very high: above 360 mg/dL, or above the number your doctor wrote above
- Your ketones are 3.0 or more, or are rising
- Your sugar is low and will not come up
- You take a -gliflozin medicine and feel very unwell, even if your sugar is normal
- You are pregnant and have ketones
Call 108 or go to the nearest hospital with an emergency department.
Questions about this sheet? Call Caspian Healthcare reception on +91 89193 41154. A doctor is on duty at all hours for problems that are not critical. Caspian has no emergency department: in an emergency call 108.
Where this comes from
- TREND Diabetes UK: type 1 diabetes, what to do when you are ill
- TREND Diabetes UK: type 2 diabetes, what to do when you are ill
- Diabetes UK: diabetes when you are unwell
- UK Medicines and Healthcare products Regulatory Agency: SGLT2 inhibitors and diabetic ketoacidosis
- American Diabetes Association: sick days
- Diabetes Canada clinical practice guidelines 2018, appendix 8: sick day medication list
Prepared by Caspian Healthcare from the sources above. Last reviewed October 2026. General information: your own doctor's written instructions come first.